High-Dose Hook Effect in an Immunochromatography–Optical Quantitative Reader Method for Myoglobin

"High-dose hook effect" with the Centocor CA 125 assay.

Supplemental Information: Cooperative Binding Mitigates the High-Dose Hook Effect

In order to explore how the high-dose Hook effect is dependent on the parameters used in our model, we repeated the simulations done for the figure entitled “Reduced hook effect in cooperative (wt) calmodulin” with a range of parameter values. First, we varied all dissociation constants by factors of 10. The results (see figure 1) show that a high-dose Hook effect is observed in all the cases. ...

Three commercial methods for serum ferritin compared and the high-dose "hook effect" eliminated.

We evaluated four commercial kits for measuring serum ferritin, based on three techniques: immunoradiometric assay, radioimmunoassay, and enzyme immunoassay. The kits evaluated were those manufactured by Abbott Laboratories, Clinical Assays, Corning Medical, and Ramco. Two of the immunoradiometric kits showed satisfactory results with respect to sensitivity and precision; they should be useful ...

High-Dose Hook Effect in 17-Hydroxyprogesterone Assay in a Patient with 21-Hydroxylase Deficiency.

Congenital adrenal hyperplasia (CAH) describes a group of disorders characterized by enzyme defects in adrenal steroidogenesis. 21-hydroxylase deficiency (21-OHD) is the most commonly encountered form. The analysis of steroids in pediatric cases requires high-sensitivity assays. A 14-year-old Syrian girl was referred for evaluation of short stature, amenorrhea, and hirsutism. On physical examin...

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...